As estrogen declines, menopause symptoms increase. S-equol, Equelle’s key ingredient, mimics estrogen in your body to help decrease menopause symptoms.
Multi-symptom menopause
relief. Guaranteed.
Simple, sophisticated, plant-based
ingredients to support women's needs




Menopause has been overlooked and
underserved for too long
See if Equelle is right for you
Supported by decades of
scientific study and research
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S-equol is plant-based and derived from soy, with decades of clinical research and results.
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We collaborate with experts and researchers in the scientific community to publish research in peer-reviewed scientific journals.
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“Equelle is one of the favorite tools in my toolbox. Patients love that it contains a plant-sourced ingredient, S-equol, and I love that it is well-studied, safe and effective.”
Multi-symptom menopause relief with
plant-based S-equol1

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Equelle’s key ingredient, S-equol, has been studied for more than 20 years
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S-equol works by safely and naturally binding to estrogen receptors
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S-equol mimics some of the beneficial effects of estrogen
Real reviews from real women
Effective. Safe. Transparent.

Equelle adheres to FDA regulations by following Current Good Manufacturing Practices (CGMP) to ensure the safety and quality of our products.

S-equol, Equelle’s active ingredient, comes from Japan. Equelle's manufacturing facilities are in the United States.
Equelle News
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WEST HILLS, Calif. (September 20, 2021) – EQUELLE, a non-prescription, hormone-free‡ supplement clinically validated to provide menopause symptom relief†, announced…
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New Campaign by EQUELLE® Encourages Women to Share their Menopause Experiences to Start an Authentic Dialogue During Menopause Awareness Month…
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WEST HILLS, Calif. (April 11, 2019) – EQUELLE, a new non-prescription, non-hormonal supplement clinically shown to alleviate the frequency of…